Adaptive Response and Radiosensitivity at Low Doses

Radiation hormesis and adoptive response induced by low doses of limiting radiation

  Ionizing radiation has long been known to produce detrimental biological effects. Although these harmful effects are the results of high doses of exposure, some other maladies such as mutation and cancer seems  to be induced at low doses of exposure. In recent decades, however, some pioneer scientists have indicated that ionizing radiation like many other essential agents has toxic effects  ...

Biologic responses to low doses of ionizing radiation: adaptive response versus bystander effect.

TO THE EDITOR: In their Newsline commentary, Drs. Feinendegen and Pollycove call an important issue to the attention of readers of The Journal of Nuclear Medicine (1). In a discussion of the dual action of ionizing radiation, they posit a competition at low doses between the direct induction of radiation damage and the activation of damage control (adaptive response, hormesis), such that below ...

Effects of capsaicin in low doses and high doses on the small intestine motor response in wild-type and TRPV1 knockout mice

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

TMPyP4 is widely considered as a potential photosensitizer in photodynamic therapy and a G-quadruplex stabilizer for telomerase-based cancer therapeutics. However, its biological effects including a possible adverse-effect are poorly understood. In this study, whole genome RNA-seq analysis was used to explore the alteration in gene expression induced by TMPyP4. Unexpectedly, we find that 27.67%...

Activation of Radioadaptive Response via Injected Serum of Irradiated Rats with Low Doses of Ionizing Radiation

Introduction: One of the protective concepts in the interpretation of radiation damage in radiobiology is the radioadaptive response. The objective of this present report is to evaluate the induction of radioadaptive response in male rats by injection of pre-irradiated serum with low doses X-radiation intraperitoneally.   Materials and Methods: 80 male adul...